The Pumas have made 7 changes to the team that humiliated the Springboks last weekend for a Test rematch in Buenos Aires Saturday.
Apart from the personnel alterations, coach Daniel Hourcade has made 2 positional switches as the Pumas seek to build on a stunning 37 / 25 win over the Springboks in Durban.
It was the 1st triumph for Argentina over South Africa after 19 failed attempts since the countries 1st met in 1993 in Buenos Aires.
And it was the 1st Rugby Championship away victory for the South Americans after 10 losses in Australia, New Zealand and South Africa over 4 seasons.
Out of the Durban starting backline go right wing Horacio Agulla, centres Marcelo Bosch, injured Jerónimo De la Fuente and scrumhalf Tomas Cubelli.
They are replaced by Santiago Cordero, Matias Moroni, Nicolas Sanchez and Martin Landajo for the match at the 50 000 capacity Estadio Jose Amalfitani in a western suburb of the Argentine capital.
Veteran Hernández, who was outstanding at flyhalf last weekend, retreats to inside centre to accommodate Sanchez in the pivotal role.
Sanchez disappointed in The Rugby Championship losses to New Zealand and Australia last month and his form will be closely monitored with the 2015 Rugby World Cup kick-off just over a month away.
Among the forwards, lock Guido Petti Pagadizabal, flank Pablo Matera and No 8 Leonardo Senatore step down.
Into their places come Benjamin Macome, Tomas Lezana and France-based 64-Test veteran Juan Martin Fernandez Lobbe.
Juan Manuel Leguizamon, another long-serving warrior in the Pumas pack, moves from the flank to No 8 in a positional alteration.
While Hourcade is rotating with the Rugby World Cup in mind, he retained props Marcos Ayerza and Nahuel Tetaz Chaparro and hooker-cum-skipper Agustin Creevy, who tormented South Africa last weekend.
The passionate Pumas dominated the scrums and breakdowns as South Africa suffered their most humiliating Test loss since a 0 / 49 meltdown in Australia 9 years ago.
It is the final Test warm-up for both countries before naming 31-man Rugby World Cup squads, with Argentina due to reveal theirs on Sunday.
South Africa are in Pool B at the global rugby showcase with Japan, Samoa, Scotland and the United States, while Argentina are in Pool C alongside Georgia, Namibia, title-holders New Zealand and Tonga.
Los Pumas: 15 Joaquin Tuculet, 14 Santiago Cordero, 13 Matias Moroni, 12 Juan Martin Hernández, 11 Juan Imhoff, 10 Nicolas Sanchez, 9 Martin Landajo, 8 Juan Manuel Leguizamon, 7 Juan Martín Fernandez Lobbe, 6 Tomas Lezana, 5 Tomas Lavanini, 4 Benjamín Macome, 3 Nahuel Tetaz Chaparro, 2 Agustín Creevy (captain), 1 Marcos Ayerza
Replacements: 16 Julian Montoya, 17 Lucas Noguera, 18 Juan Pablo Orlandi, 19 Matías Alemanno, 20 Pablo Matera, 21 Tomas Cubelli, 22 Juan Pablo Socino, 23 Lucas Gonzalez Amorosino.
Date: Saturday 15 August
Venue: Estadio Jose Amalfitani, Buenos Aires
Kick-Off: 21:40 SA Time (16:40 ARG Time, 19:40 GMT)
Referee: Glen Jackson (New Zealand)
Assistant Referees: Romain Poite (France), Mike Fraser (New Zealand)
TMO: George Ayoub (Australia)