Reds flank Liam Gill and fullback Aidan Toua were injured in the loss to the Lions in Johannesburg.
Both players had to be replaced during the match, with Toua injuring his chest after being tackled just short of the line early in the first half and Gill injuring his hamstring in a ruck in the second half.
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They will have scans on Tuesday and be assessed, but neither are expected to be available for this weekend’s match.
The Reds also lost Chris Feauai-Sautia (hamstring) and Ben Daley (knee) to injury during their two-match tour of South Africa.
Reds head coach Richard Graham said the team would need to move on quickly from the loss to the Lions and shift focus immediately to their home game against the Stormers this Saturday.
“I spoke in the lead up about the never-say-die approach of the young Lions team. They and their coach Johann Ackermann deserve plenty of credit.”
“We have been through a thorough review process today. We have a shortened preparation this week due to our travel and it is important we maximise the time we have available.”
“It is disappointing to lose Daley, Gill, Sautia and Toua during this tour but that is the nature of Super Rugby and why a strong squad is crucial.”
“The team is looking forward to getting home and playing in front of our own supporters at Suncorp Stadium. The Stormers have been unlucky but have a number of Internationals returning from injury and also a lot of class through their side.”
“I thought Gio Aplon was fantastic for them last week and Juan De Jongh added a spark in the midfield alongside Jean De Villiers.”